REGENERATIVE POTENTIAL OF DIFFERENT GROWTH FACTORS (PRP, PRF, AND CGF) IN SINUS AUGMENTATION PROCEDURES-A SYSTEMATIC REVIEW

Abstract

This study was conducted to assess the regenerative potential of blood derived growth factors such as Platelet Rich Plasma (PRP), Platelet Rich Fibrin (PRF), and Concentrated Growth Factor (CGF) used alone or in combination with graft materials during sinus augmentation procedures.

A detailed literature search was conducted of the major online databases including hand and bibliography search of all related international journals. Definite search variables were set, and specific inclusion exclusion criteria were applied to retrieve relevant articles.

Application of the definite search strategy and related parameters resulted in the retrieval of two hundred and thirty-four articles, of which only 14 articles satisfied the inclusion and exclusion criteria. Four articles were related to PRF, six to PRP and four to GCF. Only two of them reported a positive response to the use of these blood products. The clinical parameters reported were radiographic bone density, bone height changes, implant stability, marginal bone levels, implant survival rates, and histological changes.

It was concluded that further research with larger sample size and longer duration is warranted to determine the osteogenic effects of PRF, PRP and CGF. The available evidence fails to report longterm clinical outcomes on implant success rate and other related clinical parameters greater than six months period. The current literature on the clinical application of these blood derived growth factors is inadequate and limited.