INTENSITY OF WILM’S TUMOR (WT1) IMMUNOMARKER IN ORAL SQUAMOUS CELL CARCINOMA

  • Farooq Ahmad Chaudhary BDS, MPH, MDPH (Malaysia), PhD (Scholar), Senior Lecturer and Head of Department of Community Dentistry, Dental College, HITEC-IMS, Taxila Cantt.
  • Danial Qasim Butt BDS, MPhil Oral Pathology (UHS), Senior Lecturer & Head of Department of Oral Pathology, Dental College, HITEC-IMS, Taxila Cantt.
  • Naveed Mazhar Bhatti BDS, MHPE(Scholar), MSc Orthodontics, PGD Bioethics (SIUT), Associate Professor and Head of Department of Orthodontics, Dental College, HITEC-IMS, Taxila Cantt.
  • Danial Khalid BDS, MSc Oral Biology, Assistant Professor and Head of Department of Oral Biology, Dental College, HITEC-IMS, Taxila Cantt.
  • Aamir Rafiq BDS, FCPS Prosthodontics, Assistant Professor and Head of Department of Prosthodontics, Dental College, HITECIMS, Taxila Cantt.
  • Zuleikha Malik BDS, MPhil (Scholar) Dental Materials. MPhil Trainee of Dental Materials, Department of Dental Materials, National University of Medical Sciences, Rawalpindi.
Keywords: Oral Squamous Cell Carcinoma, Well Differentiated, Moderately Differentiated, Poorly Differentiated

Abstract

In oral squamous cell carcinoma (OSCC), the nests of tumor cells infilterate the underlying connective tissue of the oral squamous cell epithelium with increasing nuclear mitotic activity. In this study we are determining the role of tumor cells proliferation by evaluating the intensity of WT1 marker in OSCC. Nuclear intensity of Wilms tumor 1 (WT1) immunomarker was analyzed on sixty eight cases of well differentiated oral squamous cell carcinoma (WD-OSCC), twenty one cases of moderately differentiated oral squamous cell carcinoma (MD-OSCC) and eleven cases of poorly differentiated oral squamous cell carcinoma (PD-OSCC). Thirty seven percent (37 cases) of the cells showed 0 reactivity, thirty seven percent (37 cases) showed 1+ reactivity, twenty two percent (22 cases) showed 2+ reactivity, four percent (4 cases) showed 3+ reactivity. Seventy nine percent (54 cases) of positivity in WD-OSCC (68 cases), nineteen percent (4 cases) positivity in MD-OSCC (21 cases) and forty five percent (5 cases) positivity in PD-OSCC (11 cases). P value 0.024 significantly correlated with the histological grades of OSCC and tumor cell proliferation. The nuclear staining suggested the role of WT1 in cancer nests proliferation suggesting its oncogenic role in oral squamous cell carcinoma.

Published
2019-03-03
How to Cite
Chaudhary, F. A., Butt, D. Q., Bhatti, N. M., Khalid, D., Rafiq, A., & Malik, Z. (2019). Pakistan Oral & Dental Journal, 38(4), 432-435. Retrieved from https://podj.com.pk/index.php/podj/article/view/311
Issue
Vol. 38 No. 4 (2018): October-December 2018
Section
Oral Pathology