TOPICAL ANTISEPTICS AS SYSTEMIC ANTIBIOTICS IN THE PREVENTION OF ALVEOLAR OSTEITIS AFTER EXTRACTION OF LOWER THIRD MOLARS

  • AMJAD JAVED BDS, MMedSc (Public Health) Research Student, Karolinska University Sweden, Karolinska Institute SE-171 77 Stockholm, Sweden
  • HR SUKHIA BDS, BSc, MS, (Orth) FDSRCPS, (Glasg) FFD, (Orth) RCS, Ire MOrthRCS (Ed) For Correspondence: Prof HR Sukhia, Professor of Orthodontics & Principal (Dental) Sir Syed College of Medical Sciences for Girls, Karachi
  • YASSER RIAZ MALIK BDS, MIntPH, (Australia) Assistant Professor & HOD (Community Dentistry) Sir Syed College of Medical Sciences, St-32, Block-5, Boat Basin, Clifton, Karachi
  • MUHAMMAD SAAD SHAIKH BDS, MSc, (Oral Biology), London, Assistant Professor & HOD (Oral Biology), Sir Syed College of Medical Sciences, St-32, Block-5, Boat Basin, Clifton, Karachi
Keywords: Topical antiseptics, systemic antibiotics, alveolar osteitis

Abstract

Alveolar Osteitis (AO) and infection are common post-operative complications in third molar sur­gery. Topical antiseptics (chlorhexidine gluconate) and systemic antibiotics are the most commonly used antimicrobial agents to prevent these complications. However, their use is controversial in dental practice. The aim of this study is to evaluate the efficacy of topical antiseptics and systemic antibiotics in reducing the incidences of these complications and to compare them.

A systematic review and meta-analysis, based on clinical trials that were evaluating the efficacy of topical antiseptics and systemic antibiotics, was carried out. The primary outcome variable was AO. The relative risk (RR) of antiseptics and antibiotics as well as the total effect of all studies was calculated using random effect model.

The study included 20 clinical trials. A total of 3004 dental extractions, 868 in the antiseptic group and 2136 in the antibiotic group, were included in the quantitative analysis. The overall RR of all studies was 0.49[95% confidence interval (CI), 0.35-0.68; P < 0.001]. The RR for antiseptics was 0.42 (95& CI; 0.28-0.64; P <0.001). The RR for antibiotics was 0.56 (95% CI; 0.34-0.91; P <0.001). The difference between two groups was not statistically significant (P = 0.28).

The topical antiseptics and systemic antibiotics significantly reduce the risk of AO in third molar surgery. However, there was no difference between antiseptics and antibiotics regarding the efficacy in the prevention of AO.

Published
2017-12-31
How to Cite
JAVED, A., SUKHIA, H., MALIK, Y., & SHAIKH, M. S. (2017). TOPICAL ANTISEPTICS AS SYSTEMIC ANTIBIOTICS IN THE PREVENTION OF ALVEOLAR OSTEITIS AFTER EXTRACTION OF LOWER THIRD MOLARS. Pakistan Oral & Dental Journal, 37(4), 531-537. Retrieved from http://podj.com.pk/index.php/podj/article/view/6
Section
Oral & Maxillofacial Surgery