ESTROGEN RECEPTOR α EXPRESSION IN SALIVARY GLAND TUMORS

  • Nasiha Bashir BDS, M.Phil Assistant Professor, Department of Pathology, Peshawar Medical College, Peshawar affiliated with Riphah International University, Islamabad, Pakistan.
  • Fatima Iqbal BDS, M.Phil Assistant Professor, Department of Pathology, Peshawar Medical College, Peshawar affiliated with Riphah International University, Islamabad, Pakistan
  • Muhammad Mumtaz Khan MBBS, M.Phil (Histopathology) Professor Department of Pathology, Peshawar Medical College, Peshawar Pakistan.
  • Naveed Sharif Assistant Professor, Department of Pathology, Khyber Medical College, Peshawar affiliated with Khyber Medical University, Peshawar, Pakistan
Keywords: Salivary gland tumors, Estrogen receptors, Allred scoring

Abstract

Immunohistochemical detection of Estrogen Receptors (ER) α has demonstrated similarity between salivary glands and breast tumors. ER status is being routinely used for breast cancers in predicting response to therapy, suggesting their possible role in tumor management of SGTs. The aim of this study was to determine expression of estrogen receptor α in salivary gland tumors in both genders and various age groups.

The data of 57 already diagnosed cases of salivary gland tumors both benign and malignant were taken. They were examined microscopically for selecting the sections with maximum epithelial content for Immunohistochemical staining for ER α. Allred scoring system was used for assessing ER positivity.

Among 57 cases of salivary gland tumors 34 (59.65%) were benign and 23 (40.35%) were malignant. The ER α status was found positive in 31/57 (54.4%) of cases. Receptors positivity was present in 22 (65%) of benign and 9/23 (39%) of malignant tumors. The age range was 13-90 years. Maximum positivity for receptors (85.7%) was shown in the youngest age group (21-40 years) as compared to the oldest (above 60) which was 50.0%. Fourteen (56%) males and 17 (53.1%) females showed positivity for the ER expression.

Present study concludes that salivary gland tumors, benign or malignant, may express estrogen receptor α in any gender and age group irrespective of their histological and biological type.

Published
2018-09-10
How to Cite
Bashir, N., Iqbal, F., Khan, M. M., & Sharif, N. (2018). ESTROGEN RECEPTOR α EXPRESSION IN SALIVARY GLAND TUMORS. Pakistan Oral & Dental Journal, 38(2), 160-163. Retrieved from http://podj.com.pk/index.php/podj/article/view/170
Section
Oral Pathology